The German-African inter- and transdisciplinary CLIMAFRI project is funded by the German Federal Ministry for Education and Research (BMBF) and will develop adaptation strategies in the transboundary Lower Mono river catchment of Togo and Benin. The overall aim is to reduce the current and future flood risk considering climate change through integrating science-based data with information and knowledge from local stakeholders and communities. The project collaborates with the environmental ministries in Togo and Benin, the responsible local authorities and the Competence Center of the West African Science Service Center on Climate Change and Adapted Land Use (WASCAL) to develop a transboundary river basin information system. The sustainable use of the project results in CLIMAFRI is ensured by a proactive engagement of sector-spanning actors and the education of future decision makers and scientist within the framework of the WASCAL Graduate Program. CLIMAFRI was initiated by Togo and Benin with the concrete demand to reduce the negative impacts of flood and non-regulation of water resources. Data and tools will be made available locally and regionally in West Africa.