Patrick Stover
Director of the United Nations University Food and Nutrition Programme for Human and Social Development (UNU-FNP)
- INSTITUTE:
- UNU-FNP
- OFFICE:
- Cornell University, 127 Savage Hall, Ithaca, 14853 NY, USA
- E-MAIL:
- PHONE:
- +1 607-255-8001
- NATIONALITY:
- Not available
Research Interests
Folate-genome interactions in colon cancer and developmental anomalies Mechanisms of folate catabolism Metabolic regulation of genome methylation and stability Nuclear folate metabolism Regulation of folate-mediated one-carbon metabolismEducation
Ph.D., Biochemistry and Molecular Biophysics, Medical College of Virginia B.Sc., Chemistry, Saint Joseph's UniversityAppointments
Director, Division of Nutritional Sciences, Cornell UniversityBiographical Statement
Patrick Stover received his Bachelor of Science degree in chemistry from Saint Joseph’s University in 1987, and his Ph.D. in biochemistry and molecular biophysics in 1990 from the Medical College of Virginia. He conducted his postdoctoral research at the University of California at Berkeley in nutritional sciences from 1991 to 1994. He became an Assistant Professor of Nutritional Biochemistry in 1994 at Cornell University and currently serves as Professor and Director of the Division of Nutritional Sciences at Cornell University and as Director of the United Nations Food and Nutrition Programme for Human and Social Development.
The Stover research group investigates the biochemical, genetic and epigenetic mechanisms that underlie the relationships between the B-vitamin folate and human pathologies including neural tube defects, cardiovascular disease and cancer. Specific interests include the regulation of folate-mediated one-carbon metabolism and genome expression and stability, the molecular basis of the fetal origins hypothesis, development of mouse models to elucidate mechanisms of folate-related pathologies, and translational control of gene expression. In 1996 he received the Presidential Early Career Award for Scientists and Engineers from President William Jefferson Clinton. He received the ERL Stokstad Award in Nutritional Biochemistry from the American Society for Nutritional Sciences in 1999 and has been selected as an Outstanding Educator four times by Cornell Merrill Presidential Scholars. He is a Member of the Food and Nutrition Board of the Institute of Medicine, National Academy of Sciences. He serves on the editorial boards for the Annual Review of Nutrition, The American Journal of Clinical Nutrition and The Journal of Biological Chemistry.
Other Publications (Conference Proceedings, etc)
- MacFarlane A. J., Perry, C. A., McEntee, M. F., Lin, D. M., and Stover, P. J. 2011 Mthfd1 is a Modifier of Chemically-induced Intestinal Carcinogenesis. Carcinogenesis PMID: 21156972
- Wernimont, S. M., Raiszadeh, F., Stover, P. J., Rimm, E., Hunter, D., Tang, W. and Cassano, P. A. 2010 Polymorphisms in Serine Hydroxymethyltransferase 1 and Methylenetetrahydro-folate Reductase Interact to Increase Cardiovascular Disease Risk in Humans. J Nutr. Dec 22. [Epub ahead of print] PMID: 21178087
- MacFarlane A. J., Perry, C. A., McEntee, M. F., Lin, D. M., and Stover, P. J. (2010) Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk. Can Res (in press)
- Ching, Y-.H., Munroe, R.J., Moran, J. L., Barker, A.K., Mauceli, E., Fennell, T., diPalma, F., Lindblad-Toh, K., Abcunas, Gilmour, J.F., L.M., Harris, T.P., Kloet, S.L., Luo, Y., McElwee, J., Mu, W., Park, H.K., Rogal, D.L., Schimenti, K.J., Shen, L., Shindo, M., Shou, J.Y., Stenson, E.K., Stover, P.J. and Schimenti, J.C. (2010) High Resolution Mapping and Positional Cloning of ENU-induced Mutations in the Rw region of Mouse Chromosome 5. BMC Genet. 11(1):106. PMID: 21118569
- Stover, P.J., Harlan, W.R., Hammond, J.A., Hendershot, T., Hamilton, C.M. 2010 PhenX: An Interdisciplinary Toolkit for Genetics and Epidemiology. Curr Opin Lipidol. 21(2):136-40. PMID: 20154612
- Bentley, A. R., Raiszadeh, F., Stover, P.J., Hunter, D.J., Hankinson, S.E., and Cassano P. A. 2010 No association between cSHMT genotypes and the risk of breast cancer in the Nurses’ Health Study. Eur J Clin Nutr. 64(1):108-10. PMID: 19707223
- Fox, J. T., Shin, W. K., Caudill, M. A. and Stover, P. J. 2009 A UV-Responsive Internal Ribosome Entry Site Enhances Cytoplasmic Serine Hydroxymethyltransferase Expression for DNA Damage Repair. J. Biol. Chem. 284(45):31097-108
- Fox, J. T. and Stover, P. J. 2009 Mechanism of the Internal Ribosome Entry Site-mediated Translation of Serine Hydroxymethyltransferase 1. J. Biol. Chem. 284(45):31085-96
- Anderson, DD and Stover, PJ 2009 SHMT1 and SHMT2 are Functionally Redundant in Nuclear de novo Thymidylate Biosynthesis. PLoS One Jun 9;4(6):e5839
- MacFarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, and Stover PJ. 2009. Mthfd1 is an Essential Gene in Mice and Alters Biomarkers of Impaired One-Carbon Metabolism. J. Biol. Chem. 284(3):1533-9.
- Field MS, Anguera MC, Page R and Stover PJ. 2009. 5,10-Methenyltetrahydrofolate Synthetase Activity is Increased in Tumors and Modifies the Efficacy of Antipurine LY309887. Arch. Biochem. Biophys. 481(2):145-50.
- Macfarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, and Stover PJ. 2008. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylene-tetrahydrofolate but is not essential in mice. J. Biol. Chem . 283(38):25846-53.
- Woeller, C. F., Fox, J. T., Perry, C. and Stover, P. J. 2007. A Ferritin-responsive Internal Ribosome Entry Site Regulates Folate Metabolism. J. Biol. Chem. 282(41):29927-35.
- Anderson, D.D., Woeller, C.F., and Stover, P. J. 2007. SUMO-1 Modification of Thymidylate Synthase and Dihydrofolate Reductase. Clin. Chem. Lab. Med. 45(12): 1760-1763.
- Woeller, C. F., Anderson, D. D., Szebenyi, D. M. E. and Stover, P. J. 2007. Evidence for SUMO-Dependent Nuclear Location of the Thymidylate Biosynthesis Pathway. J. Biol. Chem. 282(24):17623-31